ncRNA name | mmu-miR-5 |
ncRNA Category | miRNA |
Disease name | age-related macular degeneration (AMD) |
Species | Mus musculus |
Tissues/Cell_line | retinas |
Methods | transduction, RT‐PCR, immunohistochemistry, fluorescein angiography |
Expression pattern | associated |
Functional description | We found significantly improved RLuc‐VEGF reporter knock‐down when two or three miRNAs were combined in the miRNA cluster compared to clusters harbouring only a single anti‐VEGF miRNA. miR‐5,10,7 was found to reduce RLuc‐VEGF reporter activity by 75% compared to miR‐irr. |
PubMed ID | 24953666 |
Year | 2014 |
Title | Development of gene therapy for treatment of age-related macular degeneration. |
Drug-related ncRNA | NO |
Copyright © Institution of Biomedical Big Data, Wenzhou Medical University All rights reserved.